Guiding the Way

Passive leg raising test with minimally invasive monitoring: the way forward for guiding septic shock resuscitation?

BACKGROUND Swift and adequate fluid loading is a cornerstone of septic shock therapy. Yet, careful assessment of volume responsiveness and volume amount during the resuscitation process is a prerequisite. Both overzealous initial fluid administration and late fluid overload are harmful and may be associated with increased mortality. MAIN BODY Static (i.e., central venous or pulmonary artery o...

Guiding the Way to Gamma-ray Sources: X-ray Studies of Supernova Remnants

Supernova remnants have long been suggested as a class of potential counterparts to unidentified γ-ray sources. The mechanisms by which such γ-rays can arise may include emission from a pulsar associated with a remnant, or a variety of processes associated with energetic particles accelerated by the SNR shock. Imaging and spectral observations in the X-ray band can be used to identify propertie...

On Parmenides' Poem: "The Way of Truth" and "The Way of Opinion"

Toward a model of consciousness: philosophical problems and questions guiding a way forward

In spite of millennia of introspection, research and debate, there is still no compelling evidence for any single model of consciousness (Dehaene & Changeux 2011). Nor is there agreement on how to define consciousness, what constitutes a rigorous model of consciousness, and what research methods are most appropriate or productive when investigating consciousness. Current science relies on biolo...

You Go That Way: Guiding Level Design in a Horror Game

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